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Publications

Forced periodic expression of G 1 cyclins phase-locks the budding yeast cell cycle

Cornell Affiliated Author(s)
Author
G. Charvin
F.R. Cross
E.D. Siggia
Abstract

Phase-locking (frequency entrainment) of an oscillator, in which a periodic extrinsic signal drives oscillations at a frequency different from the unperturbed frequency, is a useful property for study of oscillator stability and structure. The cell cycle is frequently described as a biochemical oscillator; however, because this oscillator is tied to key biological events such as DNA replication and segregation, and to cell growth (cell mass increase), it is unclear whether phase locking is possible for the cell cycle oscillator.

Journal
Proceedings of the National Academy of Sciences of the United States of America
Date Published
Research Area

A fundamental parameters approach to calibration of the mars exploration eover alpha particle X-ray spectrometer

Cornell Affiliated Author(s)
Author
J.L. Campbell
M. Lee
B.N. Jones
S.M. Andrushenko
N.G. Holmes
J.A. Maxwell
S.M. Taylor
Abstract

The detection sensitivities of the Alpha Particle X-ray Spectrometer (APXS) instruments on the Mars Exploration Rovers for a wide range of elements were experimentally determined in 2002 using spectra of geochemical reference materials. A flight spare instrument was similarly calibrated, and the calibration exercise was then continued for this unit with an extended set of geochemical reference materials together with pure elements and simple chemical compounds.

Journal
Journal of Geophysical Research: Planets
Date Published
Group (Lab)
Natasha Holmes Group

Bending and twisting of suspended single-walled carbon nanotubes in solution

Cornell Affiliated Author(s)
Author
Y.-Q. Xu
A. Barnard
P.L. McEuen
Abstract

We combine suspended carbon nanotube transistors with optical trapping techniques and scanning photocurrent microscopy to investigate the motion of suspended single-walled carbon nanotubes in solution. We study the movement of nanotubes by monitoring their photocurrent images and measure their thermal fluctuations by imaging microbeads that are tightly attached to nanotubes by single-stranded DNA. By analyzing their thermal fluctuations, we are able to obtain the torsional and bending stiffness of nanotubes and then calculate their diameters.

Journal
Nano Letters
Date Published
Group (Lab)
Paul McEuen Group

Nanoparticles for cancer treatment: Role of heat transfer

Cornell Affiliated Author(s)
Author
C.T. Avedisian
R.E. Cavicchi
P.L. McEuen
X. Zhou
Abstract

An overview is presented of an approach for treating cancer that uses nanoparticles to deliver heat to diseased areas after absorbing energy from a laser of the appropriate wavelength. The implications are discussed of the relationship of parameters necessary to raise the temperature to therapeutically beneficial levels. Tight focusing is required for a continuous-wave laser to sufficiently heat individual nanoparticles because of heat loss to the surrounding fluid during the period of exposure.

Journal
Annals of the New York Academy of Sciences
Date Published
Group (Lab)
Paul McEuen Group

Universal entanglement entropy in two-dimensional conformal quantum critical points

Cornell Affiliated Author(s)
Author
B. Hsu
M. Mulligan
E. Fradkin
Eun-Ah Kim
Abstract

We study the scaling behavior of the entanglement entropy of two-dimensional conformal quantum critical systems, i.e., systems with scale-invariant wave functions. They include two-dimensional generalized quantum dimer models on bipartite lattices and quantum loop models, as well as the quantum Lifshitz model and related gauge theories. We show that under quite general conditions, the entanglement entropy of a large and simply connected subsystem of an infinite system with a smooth boundary has a universal finite contribution, as well as scale-invariant terms for special geometries.

Journal
Physical Review B - Condensed Matter and Materials Physics
Date Published
Group (Lab)

Corner junction as a probe of helical edge states

Cornell Affiliated Author(s)
Author
C.-Y. Hou
Eun-Ah Kim
C. Chamon
Abstract

We propose and analyze interedge tunneling in a quantum spin Hall corner junction as a means to probe the helical nature of the edge states. We show that electron-electron interactions in the one-dimensional helical edge states result in Luttinger parameters for spin and charge that are intertwined, and thus rather different from those for a quantum wire with spin rotation invariance. Consequently, we find that the four-terminal conductance in a corner junction has a distinctive form that could be used as evidence for the helical nature of the edge states.

Journal
Physical Review Letters
Date Published
Group (Lab)

Vortices near the Mott phase of a trapped Bose-Einstein condensate

Cornell Affiliated Author(s)
Author
D.S. Goldbaum
E.J. Mueller
Abstract

We present a theoretical study of vortices within a harmonically trapped Bose-Einstein condensate in a rotating optical lattice. We find that proximity to the Mott insulating state dramatically affects the vortex structures. To illustrate, we give examples in which the vortices (i) all sit at a fixed distance from the center of the trap, forming a ring, or (ii) coalesce at the center of the trap, forming a giant vortex. We also model time-of-flight expansion. © 2009 The American Physical Society.

Journal
Physical Review A - Atomic, Molecular, and Optical Physics
Date Published
Funding Source
0758104

High-resolution dynamic mapping of histone-DNA interactions in a nucleosome

Cornell Affiliated Author(s)
Author
M.A. Hall
A. Shundrovsky
L. Bai
R.M. Fulbright
J.T. Lis
M.D. Wang
Abstract

The nature of the nucleosomal barrier that regulates access to the underlying DNA during many cellular processes is not fully understood. Here we present a detailed map of histone-DNA interactions along the DNA sequence to near base pair accuracy by mechanically unzipping single molecules of DNA, each containing a single nucleosome. This interaction map revealed a distinct ∼5-bp periodicity that was enveloped by three broad regions of strong interactions, with the strongest occurring at the dyad and the other two about ∼40-bp from the dyad.

Journal
Nature Structural and Molecular Biology
Date Published
Research Area
Group (Lab)
Michelle Wang Group

X-ray fluorescence imaging analysis of inscription provenance

Cornell Affiliated Author(s)
Author
J. Powers
D.-M. Smilgies
E.C. Geil
K. Clinton
N. Dimitrova
M. Peachin
R.E. Thorne
Abstract

A stone tablet from New York University considered to be a copy of an inscription from Teanum Sidinicum is examined with X-ray fluorescence (XRF) and XRF imaging. Fluorescence spectra show many of the same elements seen in ancient Roman inscriptions, but the fluorescence intensity from calcium is much weaker and that from many other elements is much stronger. The weak calcium fluorescence cannot be due to X-ray absorption by other elements present, and so the tablet is unlikely to be of marble. This conclusion is supported by X-ray diffraction and electron microprobe measurements.

Journal
Journal of Archaeological Science
Date Published
Research Area
Group (Lab)
Robert Thorne Group

Intrinsic electron and hole bands in electron-doped cuprate superconductors

Cornell Affiliated Author(s)
Author
T. Xiang
H.G. Luo
D.H. Lu
K.M. Shen
Z.X. Shen
Abstract

We propose that the upper Hubbard band (electronlike) and the Zhang-Rice singlet band (holelike) are two essential components in describing low-energy excitations of electron-doped cuprate superconductors. We find that the gap between these two bands is significantly smaller than the charge-transfer gap measured by optics and is further reduced upon doping. This indicates that the charge fluctuation is strong and the system is in the intermediate correlation regime. A two-band model is derived.

Journal
Physical Review B - Condensed Matter and Materials Physics
Date Published
Group (Lab)
Kyle Shen Group