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Publications

Mechanisms underlying WNT-mediated priming of human embryonic stem cells

Cornell Affiliated Author(s)
Author
A. Yoney
L. Bai
A.H. Brivanlou
E.D. Siggia
Abstract

Embryogenesis is guided by a limited set of signaling pathways dynamically expressed in different places. How a context-dependent signaling response is generated has been a central question of developmental biology, which can now be addressed with in vitro models of human embryos that are derived from embryonic stem cells (hESCs). Our previous work demonstrated that during early stages of hESC differentiation, cells chronicle signaling hierarchy.

Journal
Development (Cambridge)
Date Published
Funding Source
R01 GM101653
R35 GM139654
Research Area

Dynamics of spin helices in the one-dimensional XX model

Cornell Affiliated Author(s)
Author
D. Pereira
E.J. Mueller
Abstract

Motivated by cold-atom experiments and a desire to understand far-from-equilibrium quantum transport, we analytically study the dynamics of spin helices in the one-dimensional XX model. We use a Jordan-Wigner transformation to map the spin chain onto a noninteracting Fermi gas with simple equations of motion. The resulting dynamics are nontrivial, however, as the spin-helix initial condition corresponds to a highly nonequilibrium distribution of the fermions. We find a separation of timescales between the in-plane and out-of-plane spin dynamics.

Journal
Physical Review A
Date Published
Funding Source
PHY-2110250
PGSD-567963-2022

Fractional correlated insulating states at one-third filled magic angle twisted bilayer graphene

Cornell Affiliated Author(s)
Author
K. Zhang
Y. Zhang
L. Fu
Eun-Ah Kim
Abstract

The observation of superconductivity and correlated insulating states in twisted bilayer graphene has motivated much theoretical progress at integer fillings. However, little attention has been given to fractional fillings. Here we show that the three-peak structure of Wannier orbitals, dictated by the symmetry and topology of flat bands, facilitates the emergence of a state we name a “fractional correlated insulator” at commensurate fractional filling of ν = n ± 1/3.

Journal
Communications Physics
Date Published
Group (Lab)

X-ray nano-imaging of defects in thin film catalysts via cluster analysis

Cornell Affiliated Author(s)
Author
A. Luo
O.Y. Gorobtsov
J.N. Nelson
D.-Y. Kuo
T. Zhou
Z. Shao
R. Bouck
M.J. Cherukara
M.V. Holt
K.M. Shen
D.G. Schlom
J. Suntivich
A. Singer
Abstract

Functional properties of transition-metal oxides strongly depend on crystallographic defects; crystallographic lattice deviations can affect ionic diffusion and adsorbate binding energies. Scanning x-ray nanodiffraction enables imaging of local structural distortions across an extended spatial region of thin samples. Yet, localized lattice distortions remain challenging to detect and localize using nanodiffraction, due to their weak diffuse scattering.

Journal
Applied Physics Letters
Date Published
Funding Source
DE-SC0019445
DGE-2139899
ECCS-0335765
DE-AC02-06CH11357
DMR-2039380
Group (Lab)
Kyle Shen Group

Hamiltonian reconstruction as metric for variational studies

Cornell Affiliated Author(s)
Author
K. Zhang
S. Lederer
K. Choo
T. Neupert
Giuseppe Carleo
Eun-Ah Kim
Abstract

Variational approaches are among the most powerful techniques to approximately solve quantum many-body problems. These encompass both variational states based on tensor or neural networks, and parameterized quantum circuits in variational quantum eigensolvers. However, self-consistent evaluation of the quality of variational wavefunctions is a notoriously hard task. Using a recently developed Hamiltonian reconstruction method, we propose a multi-faceted approach to evaluating the quality of neural-network based wavefunctions.

Journal
SciPost Physics
Date Published
Group (Lab)

Exploring diverse students’ negotiation of lab roles through positioning

Cornell Affiliated Author(s)
Author
M. Akubo
M. Sundstrom
N.G. Holmes
Abstract

Prior work has found inequities in what experimental roles students take on during instructional labs. Research also suggests that this role division might arise implicitly and that prompting explicit role negotiation might improve equity in lab group work. To understand these various ways students negotiate roles in their lab groups, we use the lens of positioning to analyze two different video episodes of a gender-and-race-diverse group of three students.

Conference Name
Conference
Date Published
Funding Source
DGE-2139899
DUE-1836617
Group (Lab)
Natasha Holmes Group

Machine learning for automated content analysis: characteristics of training data impact reliability

Cornell Affiliated Author(s)
Author
R. Fussell
A. Mazrui
N.G. Holmes
Abstract

Natural language processing (NLP) has the capacity to increase the scale and efficiency of content analysis in Physics Education Research. One promise of this approach is the possibility of implementing coding schemes on large data sets taken from diverse contexts. Applying NLP has two main challenges, however. First, a large initial human-coded data set is needed for training, though it is not immediately clear how much training data are needed. Second, if new data are taken from a different context from the training data, automated coding may be impacted in unpredictable ways.

Conference Name
Conference
Date Published
Funding Source
DUE-2000739
Group (Lab)
Natasha Holmes Group

So Unfair it’s Fair: Equipment handling in remote versus in-person introductory physics labs

Cornell Affiliated Author(s)
Author
M. Dew
A.M. Phillips
S. Karunwi
A. Baksh
E.M. Stump
N.G. Holmes
Abstract

While understanding laboratory equipment is an important learning goal of physics laboratory (lab) instruction, previous studies have found inequities as to who gets to use equipment in in-person lab classes. With the transition to remote learning during the COVID-19 pandemic, class dynamics changed and the effects on equipment usage remain unclear. As part of a larger effort to make intro physics labs more equitable, we investigated student equipment usage based on gender and race in two introductory physics lab courses, one taught in-person and one taught remotely.

Conference Name
Conference
Date Published
Funding Source
DUE-1836617
Group (Lab)
Natasha Holmes Group

Student views of what counts as doing physics in the lab

Cornell Affiliated Author(s)
Author
E.M. Stump
N.G. Holmes
Abstract

Numerous studies have identified gender inequity in how students divide roles in lab courses. Few studies, however, have probed how these inequities impact women’s experimental physics identity development. In this work, we used closed-response surveys to investigate which lab tasks students view as part of “doing physics” and how these designations varied by gender. In both courses, we found that most students viewed working with the experimental apparatus, taking lab notes, doing data analysis, and thinking about the physics theory behind the experiment as part of doing physics.

Conference Name
Conference
Date Published
Funding Source
DGE-2139899
DUE-1836617
Group (Lab)
Natasha Holmes Group

Students’ varying responses to instructor prompts for frame shifts in physics labs

Cornell Affiliated Author(s)
Author
M. Sundstrom
R. Fussell
R.E. Scherr
N.G. Holmes
Abstract

Research has shown that students in inquiry-based physics labs often expect their experiment to verify a known theory or model, contrary to the goals of the lab. It is important, therefore, to identify ways for instructors to shift students’ expectations or epistemic frames to those in line with scientific inquiry. In this paper, we analyze video recordings of one inquiry-based lab session in which the instructor intentionally encourages students to falsify, or disprove, the claim under investigation.

Conference Name
Conference
Date Published
Funding Source
DGE-2139899
DUE-1836617
DUE-2000739
Group (Lab)
Natasha Holmes Group