Recent advances in single molecule studies of nucleosomes
Abstract
As the fundamental packing units of DNA in eukaryotes, nucleosomes play a central role in governing DNA accessibility in a variety of cellular processes. Our understanding of the mechanisms underlying this complex regulation has been aided by unique structural and dynamic perspectives offered by single molecule techniques. Recent years have witnessed remarkable advances achieved using these techniques, including the generation of a detailed histone-DNA energy landscape, elucidation of nucleosome disassembly processes, and real-time monitoring of molecular motors interacting with nucleosomes. These and other highlights of single molecule nucleosome studies will be discussed in this review. © 2011 Elsevier Ltd.
Date Published
Journal
Current Opinion in Structural Biology
Volume
22
Issue
1
Number of Pages
80-87,
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857034648&doi=10.1016%2fj.sbi.2011.11.003&partnerID=40&md5=b98d70d2aa8a5c9478bfba53f167bd0a
DOI
10.1016/j.sbi.2011.11.003
Research Area
Group (Lab)
Michelle Wang Group