Interplay between DNA supercoiling and transcription elongation
Abstract
Transcription-coupled DNA supercoiling has been shown to be an important regulator of transcription that is broadly present in the cell. Here we review experimental work which shows that RNA polymerase is a powerful torsional motor that can alter DNA topology and structure, and DNA supercoiling in turn directly affects transcription elongation. © 2014 Landes Bioscience.
Date Published
Journal
Transcription
Volume
5
Issue
APR
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84902385349&doi=10.4161%2ftrns.28636&partnerID=40&md5=e9b3c60151a48f35215e745a63aa86b0
DOI
10.4161/trns.28636
Research Area
Group (Lab)
Michelle Wang Group