In many unconventional superconductors, nematic quantum fluctuations are strongest where the critical temperature is highest, inviting the conjecture that nematicity plays an important role in the pairing mechanism. Recently, Ba1-xSrxNi2As2 has been identified as a tunable nematic system that provides an ideal testing ground for this proposition. We therefore propose several sharp empirical tests, supported by quantitative calculations in a simple model of Ba1-xSrxNi2As2. The most stringent predictions concern experiments under uniaxial strain, which has recently emerged as a powerful tuning parameter in the study of correlated materials. Since uniaxial strain so precisely targets nematic fluctuations, such experiments may provide compelling evidence for nematic-mediated pairing, analogous to the isotope effect in conventional superconductors. © 2020 authors.